Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints
نویسندگان
چکیده
منابع مشابه
Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints.
Cellular modulator of immune recognition (c-MIR) is an E3 ubiquitin ligase that ubiquitinates MHC class II and CD86 for their endocytosis and subsequent lysosomal degradation. In accordance with their importance in antigen presentation, systemic c-MIR over-expression downmodulates adaptive immune responses. Rheumatoid arthritis (RA) is a chronic synovitis driven by autoimmunity in the joints. S...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2011
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxq470